(19)

(11)

EP 0 952 849 A1

(12)

(43) Date of publication: 03.11.1999 Bulletin 1999/44 (21) Application number: 97954653.0 (22) Date of filing: 29.12.1997

(51) International Patent Classification (IPC):  A61K 39/ 04( . ) G01N 33/ 569( . ) (86) International application number: PCT/US1997/024189 (87) International publication number: WO 1998/029132 (09.07.1998 Gazette 1998/27)

(84) Designated Contracting States: DE FR GB IE IT (30) Priority: 31.12.1996 US 19960034003P (71) Applicant: NEW YORK UNIVERSITY New York, NY 10016 (US)	(72) Inventor: ZOLLA-PAZNER, Susan New York, NY 10016 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)