(19)

(11)

EP 0 953 038 A1

(12)

(43) Date of publication: 03.11.1999 Bulletin 1999/44 (21) Application number: 96938077.0 (22) Date of filing: 04.11.1996

(51) International Patent Classification (IPC):  C12P 21/ 00( . ) C07K 14/ 235( . ) C12N 1/ 38( . ) C12R 1/ 01( . ) A61K 39/ 10( . ) C12N 1/ 20( . ) A61K 39/ 00( . ) (86) International application number: PCT/EP1996/004806 (87) International publication number: WO 1997/017427 (15.05.1997 Gazette 1997/21)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 08.11.1995 GB 19950022839 (71) Applicant: SMITHKLINE BEECHAM BIOLOGICALS S.A. 1330 Rixensart (BE)	(72) Inventors: COMBERBACH, Martin B-1330 Rixensart (BE) ROELANTS, Piet B-1330 Rixensart (BE) (74) Representative: Dalton, Marcus Jonathan William, et al  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)