(19)

(11)

EP 0 954 316 A1

(12)

(43) Date of publication: 10.11.1999 Bulletin 1999/45 (21) Application number: 98945876.0 (22) Date of filing: 03.09.1998

(51) International Patent Classification (IPC):  C07D 403/ 12( . ) (86) International application number: PCT/US1998/018381 (87) International publication number: WO 1999/011269 (11.03.1999 Gazette 1999/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 03.09.1997 US 19970057472P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: ABRAHAM, Trent, Lee Bloomington, IN 47401 (US) CZESKIS, Boris Arnoldovich Carmel, IN 46432 (US) HE, Minxia Carmel, IN 46033 (US) SHIPLEY, Lisa, Ann Fishers, IN 46038 (US) (74) Representative: Hudson, Christopher Mark, et al  Lilly Industries Limited European Patent Operations Erl Wood Manor Windlesham Surrey GU20 6PH Windlesham Surrey GU20 6PH (GB)