(19)

(11)

EP 0 954 582 A1

(12)

(43) Date of publication: 10.11.1999 Bulletin 1999/45 (21) Application number: 97916597.0 (22) Date of filing: 28.04.1997

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) C07K 14/ 13( . ) A61K 39/ 175( . ) C12N 15/ 45( . ) (86) International application number: PCT/IB1997/000444 (87) International publication number: WO 1997/041236 (06.11.1997 Gazette 1997/47)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 29.04.1996 EP 19960810273 (71) Applicants: Zurbriggen, Andreas Prof. 3053 Münchenbuchsee (CH) Wittek, Ricardo, Prof. Dr. 1302 Vufflens-la-Ville (CH)	(72) Inventors: Zurbriggen, Andreas Prof. 3053 Münchenbuchsee (CH) Wittek, Ricardo, Prof. Dr. 1302 Vufflens-la-Ville (CH) (74) Representative: Blum, Rudolf Emil Ernst, et al  c/o E. Blum & Co Patentanwälte Vorderberg 11 8044 Zürich 8044 Zürich (CH)