(19)

(11)

EP 0 956 079 A1

(12)

(43) Date of publication: 17.11.1999 Bulletin 1999/46 (21) Application number: 96919086.0 (22) Date of filing: 05.06.1996

(51) International Patent Classification (IPC):  A61D 7/ 00( . ) A61M 31/ 00( . ) (86) International application number: PCT/US1996/008872 (87) International publication number: WO 1996/040351 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV SI (30) Priority: 07.06.1995 US 19950473346 07.06.1995 US 19950473347 (71) Applicant: American Cyanamid Company Madison, New Jersey 07940-0874 (US)	(72) Inventors: WOODRUFF, Keith, Floyd Mountainside, NJ 07092 (US) PETERSON, David, Alan Pipersville, PA 18947 (US) EAGER, Kendra, Beth Newtown, PA 18940 (US) (74) Representative: Mannion, Sally Kim, Dr.  c/o Wyeth Laboratories, Huntercombe Lane South, Taplow Maidenhead, Berkshire SL6 0PH Maidenhead, Berkshire SL6 0PH (GB)