(19)

(11)

EP 0 956 352 A1

(12)

(43) Date of publication: 17.11.1999 Bulletin 1999/46 (21) Application number: 97944467.0 (22) Date of filing: 26.09.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 245( . ) A61P 31/ 22( . ) C12N 15/ 38( . ) A61K 31/ 711( . ) A61K 48/ 00( . ) C07K 14/ 035( . ) (86) International application number: PCT/US1997/017262 (87) International publication number: WO 1998/014586 (09.04.1998 Gazette 1998/14)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 01.10.1996 US 19960720758 (71) Applicant: Merck & Co., Inc. (a New Jersey corp.) Rahway, N.J. 07065 (US)	(72) Inventors: ARMSTRONG, Marcy, E. Rahway, NJ 07065 (US) KEYS, Robert, D. Birmingham, AL 35222 (US) LEWIS, John, A. Rahway, NJ 07065 (US) LIU, Margaret, A. Rahway, NJ 07065 (US) McCLEMENTS, William, L. Rahway, NJ 07065 (US) (74) Representative: Thompson, John Dr.  Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)