(19)

(11)

EP 0 956 364 A1

(12)

(43) Date of publication: 17.11.1999 Bulletin 1999/46 (21) Application number: 97936237.0 (22) Date of filing: 25.07.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1997/013131 (87) International publication number: WO 1998/004742 (05.02.1998 Gazette 1998/05)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.07.1996 US 19960022636P 23.01.1997 US 19970035415P (71) Applicant: Genzyme Corporation Framingham, MA 01701-9322 (US)	(72) Inventors: HAUDENSCHILD, Dominik Brighton, MA 02135 (US) BINETTE, François Belmont, MA 02178 (US) (74) Representative: Cornish, Kristina Victoria Joy, et al  Kilburn & Strode, 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)