(19)

(11)

EP 0 957 918 A1

(12)

(43) Date of publication: 24.11.1999 Bulletin 1999/47 (21) Application number: 97952527.0 (22) Date of filing: 17.12.1997

(51) International Patent Classification (IPC):  A61K 31/ 519( . ) A61P 7/ 00( . ) A61K 31/ 5377( . ) A61P 43/ 00( . ) (86) International application number: PCT/US1997/023419 (87) International publication number: WO 1998/026781 (25.06.1998 Gazette 1998/25)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 19.12.1996 US 19960770743 (71) Applicant: American Cyanamid Company Madison, New Jersey 07940-0874 (US)	(72) Inventors: EPSTEIN, Joseph, William Monroe, NY 10950 (US) LEVIN, Jeremy, Ian Nanuet, NY 10954 (US) GIBBONS, James, Joseph Westwood, NJ 07675 (US) LUCAS, Judy Nanuet, NY 10954 (US) (74) Representative: Mannion, Sally Kim, Dr., et al  c/o Wyeth Laboratories, Huntercombe Lane South, Taplow Maidenhead, Berkshire SL6 0PH Maidenhead, Berkshire SL6 0PH (GB)