(19)

(11)

EP 0 958 304 A1

(12)

(43) Date of publication: 24.11.1999 Bulletin 1999/47 (21) Application number: 96928838.0 (22) Date of filing: 09.08.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 395( . ) A61P 19/ 02( . ) A61P 35/ 00( . ) C07K 14/ 47( . ) C07K 16/ 18( . ) C12N 1/ 21( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) A61K 31/ 7088( . ) A61K 45/ 00( . ) A61P 29/ 00( . ) A61P 35/ 02( . ) C07K 14/ 705( . ) C12N 1/ 15( . ) C12N 5/ 10( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1996/013007 (87) International publication number: WO 1998/006733 (19.02.1998 Gazette 1998/07)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: NI, Jian Rockville, MD 20853 (US) GENTZ, Reiner, L. Silver Spring, MD 20904 (US) ROSEN, Craig, A. Laytonsville, MD 20882 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)