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(11)

EP 0 958 305 A2

(12)

(43) Date of publication: 24.11.1999 Bulletin 1999/47 (21) Application number: 97935511.0 (22) Date of filing: 04.07.1997

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 45/ 00( . ) C07K 7/ 04( . ) C07K 7/ 08( . ) C12N 15/ 09( . ) A61K 38/ 00( . ) A61P 35/ 00( . ) C07K 7/ 06( . ) C07K 14/ 82( . ) C12Q 1/ 68( . ) (86) International application number: PCT/EP1997/003549 (87) International publication number: WO 1998/001467 (15.01.1998 Gazette 1998/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: RO SI (30) Priority: 05.07.1996 GB 19960014197 07.04.1997 GB 19970007041 (60) Divisional application: 06006683.4 /  (60) Divisional application: 06006747.7 /  (71) Applicants: Novartis AG 4058 Basel (CH) CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED London SW1Y 5AR (GB)

(72) Inventors: LANE, David By Saint Andrews, Fife KY16 0AL (GB) BÖTTGER, Volker D-82110 Germering-Unterpfaffenhofen (DE) BÖTTGER, Angelika D-82110 Germering-Unterpfaffenhofen (DE) PICKSLEY, Stephen Bradford, West Yorkshire BD10 0BD (GB) HOCHKEPPEL, Heinz-Kurt CH-4147 Aesch (CH) GARCIA-ECHEVERRIA, Carlos CH-4052 Basel (CH) CHENE, Patrick F-68100 Mulhouse (FR) FURET, Pascal F-68800 Thann (FR) (74) Representative: Becker, Konrad  Novartis AG Geistiges Eigentum Konzern Patent- und Markenabteilung CH Postfach 4002 Basel 4002 Basel (CH)