(19)

(11)

EP 0 958 380 A1

(12)

(43) Date of publication: 24.11.1999 Bulletin 1999/47 (21) Application number: 97952293.0 (22) Date of filing: 05.12.1997

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) (86) International application number: PCT/US1997/022296 (87) International publication number: WO 1998/024936 (11.06.1998 Gazette 1998/23)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.12.1996 US 19960032163P (71) Applicant: The Regents of The University of California Oakland, California 94612-3350 (US)	(72) Inventors: SAFINYA, Cyrus, R. Santa Barbara, CA 93106 (US) RAEDLER, Joachim, Oskar D-85748 Graching (DE) KOLTOVER, Ilya Goleta, CA 93117 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)