AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN - Patent 0960102

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EP 0 960 102 A1

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(43)	Date of publication:
	01.12.1999 Bulletin 1999/48

(21)	Application number: 97933214.0

(22)	Date of filing: 30.06.1997

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International Patent Classification (IPC):

A61K 31/ 404^{( . )}
A61K 31/ 416^{( . )}
A61K 31/ 4439^{( . )}
A61K 31/ 496^{( . )}
A61P 43/ 00^{( . )}
C07D 209/ 14^{( . )}
C07D 209/ 18^{( . )}
C07D 231/ 56^{( . )}
C07D 307/ 79^{( . )}
C07D 401/ 06^{( . )}
C07D 403/ 06^{( . )}
C07D 403/ 12^{( . )}
C07D 471/ 04^{( . )}

A61K 31/ 41^{( . )}
A61K 31/ 4184^{( . )}
A61K 31/ 454^{( . )}
A61P 7/ 02^{( . )}
C07D 209/ 08^{( . )}
C07D 209/ 16^{( . )}
C07D 231/ 12^{( . )}
C07D 235/ 06^{( . )}
C07D 333/ 58^{( . )}
C07D 401/ 12^{( . )}
C07D 403/ 10^{( . )}
C07D 405/ 14^{( . )}

(86)	International application number:
	PCT/US1997/011325

(87)	International publication number:
	WO 1998/001428 (15.01.1998 Gazette 1998/02)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

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Priority:

08.07.1996 US 19960676766
13.06.1997 US 19970049519P

(71)	Applicant: Du Pont Pharmaceuticals Company
	Wilmington, DE 19898 (US)

(72)	Inventors:
	DOMINGUEZ, Celia Newark, DE 19711 (US) HAN, Qi Wilmington, DE 19810 (US) DUFFY, Daniel, Emmett Wilmington, DE 19803 (US) PARK, Jeongsook, Maria Bear, DE 19701 (US) QUAN, Mimi, Lifen Newark, DE 19711 (US) ROSSI, Karen, Anita Wilmington, DE 19808 (US) WEXLER, Ruth, Richmond Wilmington, DE 19810 (US)

(74)	Representative: Pett, Christopher Phineas
	Frank B. Dehn & Co., European Patent Attorneys, 179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)

(54)	AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN