(19)

(11)

EP 0 960 198 A1

(12)

(43) Date of publication: 01.12.1999 Bulletin 1999/48 (21) Application number: 96927373.0 (22) Date of filing: 09.08.1996

(51) International Patent Classification (IPC):  C07K 14/ 705( . ) C12N 15/ 12( . ) C12N 1/ 21( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1996/013008 (87) International publication number: WO 1998/006839 (19.02.1998 Gazette 1998/07)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: NI, Jian Rockville, MD 20853 (US) GENTZ, Reiner, L. Rockville, Maryland 20850 (US) DILLON, Patrick, J. Gaithersburg, MD 20879 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)