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EP 0 961 793 A1

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(43) Date of publication: 08.12.1999 Bulletin 1999/49 (21) Application number: 98901884.0 (22) Date of filing: 10.02.1998

(51) International Patent Classification (IPC):  A61K 39/ 08( . ) A61K 39/ 09( . ) A61K 39/ 385( . ) A61P 31/ 04( . ) C07K 14/ 11( . ) C07K 16/ 10( . ) C07K 17/ 08( . ) C08F 220/ 34( . ) C08F 222/ 32( . ) A61K 39/ 00( . ) A61K 39/ 085( . ) A61K 39/ 145( . ) A61K 47/ 48( . ) A61P 31/ 16( . ) C07K 14/ 315( . ) C07K 16/ 12( . ) C08F 220/ 26( . ) C08F 220/ 54( . ) C08F 246/ 00( . ) (86) International application number: PCT/AU1998/000076 (87) International publication number: WO 1998/034968 (13.08.1998 Gazette 1998/32)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 11.02.1997 AU 1997PO05071 03.10.1997 CA 19972217321 (71) Applicants: THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH Herston, QLD 4029 (AU) COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION Campbell, Australian Capital Territory 2601 (AU) THE UNIVERSITY OF MELBOURNE Parkville, VIC 3052 (AU) THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH Parkville, VIC 3052 (AU) CSL LIMITED Parkville, VIC 3052 (AU)

(72) Inventors: JACKSON, David, Charles North Balwyn, VIC 3104 (AU) O'BRIEN-SIMPSON, Neil, Martin Brunswick, VIC 3056 (AU) BROWN, Lorena, Elizabeth North Balwyn, VIC 3104 (AU) ZENG, Wieguang North Melbourne, VIC 3051 (AU) EDE, Nicholas, Jon East Malvern, VIC 3145 (AU) BRANDT, Evelyn, Rosemary Windsor, QLD 4030 (AU) GOOD, Michael, Francis The Gap, QLD 4061 (AU) (74) Representative: Sheard, Andrew Gregory, et al  Kilburn & Strode 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)