(19)

(11)

EP 0 963 205 A1

(12)

(43) Date of publication: 15.12.1999 Bulletin 1999/50 (21) Application number: 96933739.0 (22) Date of filing: 23.08.1996

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61P 43/ 00( . ) C07K 16/ 28( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) A61K 38/ 00( . ) A61K 39/ 395( . ) C07K 14/ 705( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) G01N 33/ 566( . ) (86) International application number: PCT/US1996/013768 (87) International publication number: WO 1998/007754 (26.02.1998 Gazette 1998/08)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: NI, Jian Rockville, MD 20853 (US) GENTZ, Reiner, L. Silver Spring, MD 20904 (US) RUBEN, Steven, M. Olney, MD 20832 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)