(19)
(11) EP 0 963 434 A1

(12)

(43) Date of publication:
15.12.1999 Bulletin 1999/50

(21) Application number: 97944487.0

(22) Date of filing: 26.09.1997
(51) International Patent Classification (IPC): 
A61K 38/ 45( . )
C07K 14/ 47( . )
C12N 9/ 10( . )
A61K 48/ 00( . )
C12N 7/ 00( . )
C12N 15/ 10( . )
(86) International application number:
PCT/US1997/017302
(87) International publication number:
WO 1998/013485 (02.04.1998 Gazette 1998/13)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 27.09.1996 US 19960037742P

(71) Applicants:
  • Maxygen, Inc.
    Redwood City 94063 (US)
  • Introgene B.V.
    2301 CA Leiden (NL)

(72) Inventors:
  • STEMMER, Willem, P., C.
    Los Gatos, CA 95030 (US)
  • VAN ES, Helmuth, H., G.
    NL-2133 DJ Hoofddorp (NL)

(74) Representative: Irvine, Jonquil Claire 
J.A. KEMP & CO. 14 South Square Gray's Inn
London WC1R 5LX
London WC1R 5LX (GB)

   


(54) METHODS FOR OPTIMIZATION OF GENE THERAPY BY RECURSIVE SEQUENCE SHUFFLING AND SELECTION