C-TERMINAL KETONE HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES AND TNFA SECRETION - Patent 0964851

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EP 0 964 851 A1

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(43)	Date of publication:
	22.12.1999 Bulletin 1999/51

(21)	Application number: 98902771.0

(22)	Date of filing: 07.01.1998

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International Patent Classification (IPC):

A61K 31/ 165^{( . )}
A61K 31/ 381^{( . )}
A61K 31/ 4184^{( . )}
A61K 31/ 426^{( . )}
A61P 19/ 02^{( . )}
A61P 29/ 00^{( . )}
A61P 43/ 00^{( . )}
C07C 259/ 06^{( . )}
C07D 207/ 335^{( . )}
C07D 213/ 50^{( . )}
C07D 263/ 32^{( . )}
C07D 277/ 28^{( . )}
C07D 333/ 22^{( . )}

A61K 31/ 197^{( . )}
A61K 31/ 404^{( . )}
A61K 31/ 421^{( . )}
A61K 31/ 4406^{( . )}
A61P 19/ 10^{( . )}
A61P 35/ 00^{( . )}
C07C 233/ 32^{( . )}
C07D 207/ 323^{( . )}
C07D 209/ 14^{( . )}
C07D 235/ 14^{( . )}
C07D 277/ 24^{( . )}
C07D 277/ 30^{( . )}
C07D 207/ 32^{( . )}

(86)	International application number:
	PCT/US1998/000142

(87)	International publication number:
	WO 1998/030541 (16.07.1998 Gazette 1998/28)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

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Priority:

07.01.1997 US 19970779778

(71)	Applicant: Abbott Laboratories
	Abbott Park, Illinois 60064-3500 (US)

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Inventors:

DAVIDSEN, Steven, K.
Libertyville, IL 60048 (US)
FLORJANCIC, Alan, Scott
Lake Bluff, IL 60044 (US)
SHEPPARD, George, S.
Wilmette, IL 60091 (US)
GIESLER, Jamie, R.
Oak Creek, WI 53154 (US)
XU, Lianhong
Libertyville, IL 60048 (US)
GUO, Yan
Gurnee, IL 60031 (US)
CURTIN, Michael, L.
Kenosha, WI 53242 (US)
MICHAELIDES, Michael, R.
Gurnee, IL 60031 (US)
WADA, Carol, K.
Grayslake, IL 60030 (US)
HOLMS, James, H.
Gurnee, IL 60031 (US)

(74)	Representative: Modiano, Guido, Dr.-Ing., et al
	Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)

(54)	C-TERMINAL KETONE HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES AND TNFA SECRETION