METHODS FOR OPTIMIZATION OF GENE THERAPY BY RECURSIVE SEQUENCE SHUFFLING AND SELECTION

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EP 0 964 922 A1

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(43)	Date of publication:
	22.12.1999 Bulletin 1999/51

(21)	Application number: 97943600.0

(22)	Date of filing: 26.09.1997

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International Patent Classification (IPC):

G01N 33/ 50^{( . )}
A61K 48/ 00^{( . )}
C12N 9/ 10^{( . )}
C12N 15/ 10^{( . )}

A61K 38/ 45^{( . )}
C12N 7/ 00^{( . )}
C12N 15/ 09^{( . )}
G01N 33/ 15^{( . )}

(86)	International application number:
	PCT/US1997/017300

(87)	International publication number:
	WO 1998/013487 (02.04.1998 Gazette 1998/13)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

27.09.1996 US 19960037742P
27.09.1996 US 19960722660

(71)	Applicant: Maxygen, Inc.
	Santa Clara, CA 95051 (US)

(72)	Inventors:
	STEMMER, Willem, P., C. Los Gatos, CA 95030 (US) CHRISTIANS, Frederick, C. Los Altos, CA 94024 (US) LIU, Shi-Kau Cupertino, CA 95014 (US)

(74)	Representative: Irvine, Jonquil Claire
	J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)

(54)	METHODS FOR OPTIMIZATION OF GENE THERAPY BY RECURSIVE SEQUENCE SHUFFLING AND SELECTION