(19)

(11)

EP 0 966 269 A1

(12)

(43) Date of publication: 29.12.1999 Bulletin 1999/52 (21) Application number: 98949575.0 (22) Date of filing: 28.09.1998

(51) International Patent Classification (IPC):  A61K 9/ 16( . ) A61K 31/ 192( . ) A61K 9/ 20( . ) A61P 29/ 00( . ) (86) International application number: PCT/US1998/020266 (87) International publication number: WO 1999/017744 (15.04.1999 Gazette 1999/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL SE (30) Priority: 07.10.1997 US 19970946070 05.08.1998 US 19980129164 (71) Applicant: Fuiz Technologies Ltd. Chantilly, VA 20151 (US)

(72) Inventors: FRISBEE, Steven, E. Reston, VA 22091 (US) BARROW, Deirdre, M. Fairfax, VA 22030 (US) CASCONE, Joseph Chantilly, VA 20151 (US) MCCARTHY, Barry, D. Centreville, VA 20120 (US) KIERNAN, Bernard, M. Sterling, VA 20164 (US) ANWAR, Hanan, S. Bridgewater, NJ 08807 (US) BOGUE, Beuford, A. Broad Run, VA 20137 (US) BAYARD, Claude Arlington, VA 22202 (US) BANERJEE, Abhijit Alexandria, VA 22311 (US) (74) Representative: McKeown, Yvonne Mary, et al  c/o MacLachlan & Donaldson, 47 Merrion Square Dublin 2 Dublin 2 (IE)