(19)

(11)

EP 0 966 472 A1

(12)

(43) Date of publication: 29.12.1999 Bulletin 1999/52 (21) Application number: 97950724.0 (22) Date of filing: 21.11.1997

(51) International Patent Classification (IPC):  A61K 31/ 546( . ) C07D 501/ 00( . ) A61P 31/ 04( . ) C07D 501/ 36( . ) (86) International application number: PCT/US1997/021785 (87) International publication number: WO 1998/023621 (04.06.1998 Gazette 1998/22)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.11.1996 US 19960034046P (71) Applicant: Bristol-Myers Squibb Company Wallingford, CT 06492-7660 (US)	(72) Inventors: SPRINGER, Dane, M. Meriden, CT 06450 (US) LUH, Bing, Y. Killingworth, CT 06417 (US) D'ANDREA, Stanley, V. Middletown, CT 06457 (US) HUDYMA, Thomas, W. Durham, CT 06422 (US) KIM, Oak K. Guilford, CT 06437 (US) (74) Representative: Jones, Alan John, et al  CARPMAELS & RANSFORD 43 Bloomsbury Square London, WC1A 2RA London, WC1A 2RA (GB)