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(11)

EP 0 966 478 A1

(12)

(43) Date of publication: 29.12.1999 Bulletin 1999/52 (21) Application number: 97910705.0 (22) Date of filing: 07.10.1997

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) C07K 14/ 46( . ) C12N 15/ 09( . ) G01N 33/ 68( . ) C07K 14/ 435( . ) C07K 14/ 47( . ) G01N 33/ 50( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1997/015753 (87) International publication number: WO 1998/030576 (16.07.1998 Gazette 1998/28)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 07.10.1996 US 19960729743 02.10.1997 US 19970061323P (71) Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE Baltimore, MD 21205 (US)	(72) Inventors: BEACHY, Philip, A. Baltimore, MD 21209 (US) PORTER, Jeffrey, A. Baltimore, MD 21218 (US) (74) Representative: Dost, Wolfgang, Dr.rer.nat., Dipl.-Chem., et al  Patent- und Rechtsanwälte Bardehle . Pagenberg . Dost . Altenburg . Geissler . Isenbruck Galileiplatz 1 81679 München 81679 München (DE)