(19)

(11)

EP 0 967 878 A1

(12)

(43) Date of publication: 05.01.2000 Bulletin 2000/01 (21) Application number: 97947273.5 (22) Date of filing: 23.10.1997

(51) International Patent Classification (IPC)7: A01N 63/00, A61K 38/00, A61K 38/16, A61K 39/00, A61K 39/395, A61K 48/00, C07K 14/00, C07K 16/46, C07K 19/00, C12N 5/00, C12N 5/08 (86) International application number: PCT/US9719/206 (87) International publication number: WO 9817/116 (30.04.1998 Gazette 1998/17)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.10.1996 US 740003 (71) Applicant: WAKE FOREST UNIVERSITY Winston-Salem, NC 27157-1023 (US)	(72) Inventor: CHEN, Si-Yi Advance, NC 27006 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & SchwanhäusserAnwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)