(19)

(11)

EP 0 968 282 A2

(12)

(88) Date of publication A3: 14.01.1999 (43) Date of publication: 05.01.2000 Bulletin 2000/01 (21) Application number: 98910152.2 (22) Date of filing: 05.03.1998

(51) International Patent Classification (IPC)7: C12N 15/00 (86) International application number: PCT/US9804/155 (87) International publication number: WO 9839/425 (11.09.1998 Gazette 1998/36)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.03.1997 US 3719 P (71) Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Rockville, MD 20852-3804 (US)	(72) Inventor: NEVILLE, David, M. Bethesda, MD 20814 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & SchwanhäusserAnwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)