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(11)

EP 0 968 289 A1

(12)

(43) Date of publication: 05.01.2000 Bulletin 2000/01 (21) Application number: 98953918.4 (22) Date of filing: 22.10.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C12N 15/11, C07K 16/28, C07K 16/42 (86) International application number: PCT/US9822/442 (87) International publication number: WO 9920/762 (29.04.1999 Gazette 1999/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.10.1997 US 955661 (71) Applicant: ICOS CORPORATION Bothell, WA 98021 (US)	(72) Inventors: LOUGHNEY, Kate Seattle, WA 98115 (US) STAUNTON, Donald, E. Kirkland, WA 98033 (US) VAZEAU, Rosemay Seattle, WA 98119 (US) (74) Representative: Richardson, Kate et al Forrester & Boehmert,Franz-Joseph Strasse 38 80801 München 80801 München (DE)