(19)

(11)

EP 0 968 298 A2

(12)

(88) Date of publication A3: 17.12.1998 (43) Date of publication: 05.01.2000 Bulletin 2000/01 (21) Application number: 98910147.2 (22) Date of filing: 03.03.1998

(51) International Patent Classification (IPC)7: C12N 15/86, C12N 5/10, A61K 48/00, A61K 47/48, C12Q 1/70, C12N 11/08 (86) International application number: PCT/US9804/133 (87) International publication number: WO 9839/467 (11.09.1998 Gazette 1998/36)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.03.1997 US 39763 P 02.03.1998 US  (71) Applicant: Calydon, Inc. Sunnyvale, CA 94089 (US)	(72) Inventors: LAMPARSKI, Henry, G. San Mateo, CA 94402 (US) HENERSON, Daniel, R. Palo Alto, CA 94306 (US) SCHUUR, Eric, R. Cupertino, CA 95014 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)