(19)

(11)

EP 0 968 301 A2

(12)

(88) Date of publication A3: 10.12.1998 (43) Date of publication: 05.01.2000 Bulletin 2000/01 (21) Application number: 98913699.9 (22) Date of filing: 11.03.1998

(51) International Patent Classification (IPC)7: C12P 19/14, C12N 9/38, C12N 9/24, C07H 3/06 (86) International application number: PCT/EP9801/393 (87) International publication number: WO 9840/512 (17.09.1998 Gazette 1998/37)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB IE IT LI NL PT SE Designated Extension States: SI (30) Priority: 13.03.1997 IT MI970566 (71) Applicant: Societa' Cooperativa Centro Ricercher Poly-Tech a Responsabilita' Limitata 34012 Trieste (IT)	(72) Inventors: PAOLETTI, Sergio I-34100 Trieste (IT) VETERE, Amedeo I-80027 Fratta Maggiore (IT) (74) Representative: Gervasi, Gemma, Dr.  NOTARBARTOLO & GERVASI Srl,Corso di Porta Vittoria, 9 20122 Milano 20122 Milano (IT)