(19)

(11)

EP 0 969 840 A1

(12)

(43) Date of publication: 12.01.2000 Bulletin 2000/02 (21) Application number: 98911875.7 (22) Date of filing: 20.03.1998

(51) International Patent Classification (IPC)7: A61K 31/495, A61K 31/535, C07D 401/14, C07D 403/12, C07D 413/06 (86) International application number: PCT/US9805/486 (87) International publication number: WO 9842/342 (01.10.1998 Gazette 1998/39)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 24.03.1997 US 41543 P 22.05.1997 US 47561 P 08.08.1997 GB 9716872 06.01.1998 GB 9800214 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: ISAACS, Richard, C., A. Rahway, NJ 07065 (US) NAYLOR-OLSEN, Adel, M. Rahway, NJ 07065 (US) DORSEY, Bruce, D. Rahway, NJ 07065 (US) NEWTON, Christina, L. Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)