(19)

(11)

EP 0 969 848 A1

(12)

(43) Date of publication: 12.01.2000 Bulletin 2000/02 (21) Application number: 98901777.7 (22) Date of filing: 13.01.1998

(51) International Patent Classification (IPC)7: A61K 31/70 (86) International application number: PCT/US9800/546 (87) International publication number: WO 9830/222 (16.07.1998 Gazette 1998/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI PT SE (30) Priority: 13.01.1997 US 35819 P (71) Applicant: Clemson University Clemson,South Carolina 29634 (US)	(72) Inventors: HILDERMAN, Richard, H. Liberty, SC 29657 (US) SWINDLE, M., Michael Mr. Pleasant, SC 29464 (US) (74) Representative: Grünecker, August, Dipl.-Ing. et al PatentanwälteGrünecker, Kinkeldey, Stockmair & PartnerMaximilianstrasse 58 80538 München 80538 München (DE)