(19)

(11)

EP 0 970 210 A1

(12)

(43) Date of publication: 12.01.2000 Bulletin 2000/02 (21) Application number: 98912175.1 (22) Date of filing: 26.03.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, A61K 38/17, A61K 48/00, G01N 33/68, G01N 33/53 (86) International application number: PCT/CA9800/277 (87) International publication number: WO 9844/102 (08.10.1998 Gazette 1998/40)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.03.1997 US 828158 (71) Applicant: UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. Calgary,Alberta T2N 2A1 (CA)	(72) Inventors: HELBING, Caren, C. Calgary, Alberta T2N 4M1 (CA) RIABOWOL, Karl Calgary, Alberta T2P 2G5 (CA) JOHNSTON, Randall, N. Calgary, Alberta T3A 4C3 (CA) GARKAVTSEV, Igor Calgary, Alberta T2T 4W1 (CA) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)