(19)

(11)

EP 0 971 742 A1

(12)

(43) Date of publication: 19.01.2000 Bulletin 2000/03 (21) Application number: 98902618.2 (22) Date of filing: 16.01.1998

(51) International Patent Classification (IPC)7: A61K 45/05, A61K 38/00, A61K 38/19, C07K 1/00, C07K 14/52 (86) International application number: PCT/US9800/939 (87) International publication number: WO 9831/391 (23.07.1998 Gazette 1998/29)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 17.01.1997 US 35714 P 07.08.1997 US 54886 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventor: RINELLA, Joseph, V., Jr. Brownsburg, IN 46112 (US) (74) Representative: Denholm, Anna Marie  Eli Lilly and Company Limited,Lilly Research Center,Erl Wood Manor Windlesham,Surrey GU20 6PH Windlesham,Surrey GU20 6PH (GB)