(19)

(11)

EP 0 971 746 A1

(12)

(43) Date of publication: 19.01.2000 Bulletin 2000/03 (21) Application number: 98908843.0 (22) Date of filing: 03.03.1998

(51) International Patent Classification (IPC)7: A61K 47/10, A61K 9/00, A61K 9/10, A61K 31/495, A61K 31/535 (86) International application number: PCT/US9804/033 (87) International publication number: WO 9843/673 (08.10.1998 Gazette 1998/40)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 31.03.1997 US 829091 (71) Applicant: Johnson & Johnson Consumer Companies, Inc. Skillman,New Jersey 08558-9418 (US)	(72) Inventors: RAO, Chakradhara Somerville, NJ 08876-5304 (US) LIU, Jue-Chen Neshanic, NJ 08853 (US) WANG, Jonas, C., T. Robbinsville, NJ 08691 (US) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)