(19)

(11)

EP 0 971 910 A1

(12)

(43) Date of publication: 19.01.2000 Bulletin 2000/03 (21) Application number: 98913487.9 (22) Date of filing: 31.03.1998

(51) International Patent Classification (IPC)7: C07D 307/58, A61K 31/34, C07D 405/06, C07C 317/24, C07C 317/14 (86) International application number: PCT/CA9800/302 (87) International publication number: WO 9843/966 (08.10.1998 Gazette 1998/40)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 02.04.1997 US 42535 P 07.05.1997 GB 9709356 (71) Applicant: Merck Frosst Canada & Co. Kirkland, Quebec H9H 3L1 (CA)	(72) Inventors: LEGER, Serge Kirkland, Quebec H9H 3L1 (CA) GRIMM, Erich Kirkland, Quebec H9H 3L1 (CA) PRASIT, Petpiboon Kirkland, Quebec H9H 3L1 (CA) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)