(19)

(11)

EP 0 971 952 A2

(12)

(88) Date of publication A3: 15.04.1999 (43) Date of publication: 19.01.2000 Bulletin 2000/03 (21) Application number: 98917502.1 (22) Date of filing: 02.04.1998

(51) International Patent Classification (IPC)7: C07K 14/00, C12Q 1/68, G01N 33/53, C12N 15/85, A61K 48/00 (86) International application number: PCT/IB9800/705 (87) International publication number: WO 9845/322 (15.10.1998 Gazette 1998/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.04.1997 US 43163 P (71) Applicants: Royal Netherlands Academy of Arts and Sciences 1000 GC Amsterdam (NL) Erasmus Universiteit Rotterdam 3000 DR Rotterdam (NL) Universiteit Utrecht 3584 CG Utrecht (NL)	(72) Inventors: VAN LEEUWEN, Frederik, W. NL-3063 CL Maarssen (NL) GROSVELD, Franklin, G. NL-3065 NH Rotterdam (NL) BURBACH, Johannes, Peter, Henri NL-3981 SB Bunnik (NL) (74) Representative: Ottevangers, Sietse Ulbe et al Vereenigde OctrooibureauxNieuwe Parklaan 97 2587 BN 's-Gravenhage 2587 BN 's-Gravenhage (NL)