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EP 0 971 957 A1

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(43) Date of publication: 19.01.2000 Bulletin 2000/03 (21) Application number: 98909375.2 (22) Date of filing: 26.03.1998

(51) International Patent Classification (IPC)7: C07K 14/48, A61K 38/18, C07K 14/595 (86) International application number: PCT/DK9800/128 (87) International publication number: WO 9842/747 (01.10.1998 Gazette 1998/39)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.03.1997 DK 35897 19.11.1997 DK 131597 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: HASTRUP, Sven DK-2200 Copenhagen N (DK) CHRISTIANSEN, Kennet DK-2610 R dovre (DK) THIM, Lars DK-2820 Gentofte (DK) JUDGE, Martin, Edward DK-1363 Copenhagen K (DK) KRISTENSEN, Peter DK-2700 Br nsh j (DK) (74) Representative: Stephensen, Birgitte Borregaard (DK)  c/o Novo Nordisk A/SCorporate PatentsNovo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)