(19)

(11)

EP 0 972 013 A1

(12)

(43) Date of publication: 19.01.2000 Bulletin 2000/03 (21) Application number: 98914305.2 (22) Date of filing: 24.03.1998

(51) International Patent Classification (IPC)7: C12N 5/00, C12N 15/00, C07H 21/02, C07H 21/04 (86) International application number: PCT/US9805/866 (87) International publication number: WO 9842/826 (01.10.1998 Gazette 1998/39)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.03.1997 US 822509 (71) Applicant: RESEARCH CORPORATION TECHNOLOGIES Tucson,Arizona 85711-3335 (US)	(72) Inventors: CRISH, James, F. North Olmsted, OH 44070 (US) ECKERT, Richard, L. Cleveland Heights, OH 44106 (US) (74) Representative: Glawe, Delfs, Moll & Partner  PatentanwälteRothenbaumchaussee 58 20148 Hamburg 20148 Hamburg (DE)