(19)

(11)

EP 0 973 521 A1

(12)

(43) Date of publication: 26.01.2000 Bulletin 2000/04 (21) Application number: 97911336.2 (22) Date of filing: 05.11.1997

(51) International Patent Classification (IPC)7: A61K 31/52 (86) International application number: PCT/GB9703/036 (87) International publication number: WO 9819/679 (14.05.1998 Gazette 1998/19)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.11.1996 GB 9622981 (71) Applicant: University of Wales College of Medicine Cardiff CF4 4XN (GB)	(72) Inventors: McPHERSON, Margaret Ann Ogmore-by-Sea,Mid Glamorgan CF32 0PG (GB) DORMER, Robert Leslie Ogmore-by-Sea,Mid Glamorgan CF32 0PG (GB) PEREIRE, Malcolm Martin Claude Ogmore-by-Sea,Mid Glamorgan CF32 0PG (GB) (74) Representative: Eastwood, Simon Christopher et al Wynne-Jones, Lainé & James,Morgan Arcade Chambers,33 St. Mary Street Cardiff CF1 2AB Cardiff CF1 2AB (GB)