(19)

(11)

EP 0 973 553 A2

(12)

(88) Date of publication A3: 28.01.1999 (43) Date of publication: 26.01.2000 Bulletin 2000/04 (21) Application number: 98918097.1 (22) Date of filing: 10.04.1998

(51) International Patent Classification (IPC)7: A61K 49/04, A61K 51/04, A61K 51/06, A61K 101/02, A61K 123/00 (86) International application number: PCT/US9807/239 (87) International publication number: WO 9846/275 (22.10.1998 Gazette 1998/42)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 11.04.1997 US 43305 P (71) Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF MICHIGAN Ann Arbor,Michigan 48109-1280 (US)	(72) Inventors: COUNSELL, Raymond, E. Ann Arbor, MI 48103 (US) LONGINO, Marc, A. Ann Arbor, MI 48103 (US) WEICHERT, Jamey, P. Ann Arbor, MI 48103 (US) (74) Representative: West, Alan Harry et al R.G.C. Jenkins & Co.26 Caxton Street London SW1H 0RJ London SW1H 0RJ (GB)