(19)
(11) EP 0 973 742 A1

(12)

(43) Date of publication:
26.01.2000 Bulletin 2000/04

(21) Application number: 98902416.1

(22) Date of filing: 09.01.1998
(51) International Patent Classification (IPC)7: C07D 213/30, C07D 213/48, A61K 31/44, C07B 37/02
(86) International application number:
PCT/US9800/263
(87) International publication number:
WO 9830/543 (16.07.1998 Gazette 1998/28)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
Designated Extension States:
RO SI

(30) Priority: 14.01.1997 US 35462 P
21.03.1997 GB 9705858

(71) Applicant: MERCK & CO., INC.
Rahway, New Jersey 07065 (US)

(72) Inventors:
  • TILLYER, Richard, D.
    Rahway, NJ 07065 (US)
  • XU, Feng
    Rahway, NJ 07065 (US)
  • TSCHAEN, David, M.
    Rahway, NJ 07065 (US)

(74) Representative: Thompson, John Dr. 
Merck & Co., Inc.European Patent DepartmentTerlings ParkEastwick Road
Harlow, Essex CM20 2QR
Harlow, Essex CM20 2QR (GB)

   


(54) ENDOTHELIN INTERMEDIATES BY ASYMMETRIC CONJUGATE ADDITION REACTION USING A CHIRAL ADDITIVE