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EP 0 973 778 A1

(12)

(43) Date of publication: 26.01.2000 Bulletin 2000/04 (21) Application number: 98906858.0 (22) Date of filing: 06.03.1998

(51) International Patent Classification (IPC)7: C07D 495/04, C07D 217/06, A61K 31/435, A61K 31/47 (86) International application number: PCT/DK9800/083 (87) International publication number: WO 9840/385 (17.09.1998 Gazette 1998/37)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.03.1997 DK 24997 27.11.1997 DK 136597 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)

(72) Inventors: MADSEN, Peter DK-2880 Bagsvaerd (DK) LUNDBECK, Jane, Marie DK-2600 Glostrup (DK) WESTERGAARD, Niels DK-3500 Vaerlose (DK) NAERUM, Lars DK-2900 Hellerup (DK) VARMING, Annemarie, Reinhardt DK-2920 Charlottenlund (DK) DEMUTH, Helle DK-2970 Horsholm (DK) HEIDE, Morten DK-2840 Holte (DK) (74) Representative: Jensen, Bo Hammer et al Novo Nordisk A/S,Health Care Patents,Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)