(19)

(11)

EP 0 973 876 A1

(12)

(43) Date of publication: 26.01.2000 Bulletin 2000/04 (21) Application number: 98910855.0 (22) Date of filing: 05.03.1998

(51) International Patent Classification (IPC)7: C12N 9/58, C12N 15/55, C07K 16/14 (86) International application number: PCT/GB9800/704 (87) International publication number: WO 9839/424 (11.09.1998 Gazette 1998/36)

(84) Designated Contracting States: DE ES FR GB IT NL (30) Priority: 05.03.1997 GB 9704559 (71) Applicant: ISIS INNOVATION LIMITED Oxford OX1 3UB (GB)	(72) Inventor: WAKEFIELD, Ann, Elizabeth Charlbury,Oxford OX7 3ET (GB) (74) Representative: Pennant, Pyers  Stevens, Hewlett & Perkins,1 Serjeants' Inn,Fleet Street London EC4Y 1NT London EC4Y 1NT (GB)