(19)

(11)

EP 0 973 882 A1

(12)

(43) Date of publication: 26.01.2000 Bulletin 2000/04 (21) Application number: 98914390.4 (22) Date of filing: 31.03.1998

(51) International Patent Classification (IPC)7: C12N 15/00, C12N 15/09, C12N 15/29, C12N 15/82, A01H 1/00, A01H 3/00, A01H 4/00, A01H 5/00 (86) International application number: PCT/US9806/405 (87) International publication number: WO 9845/425 (15.10.1998 Gazette 1998/41)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.04.1997 US 834900 (71) Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. Gainesville, FL 32611 (US)	(72) Inventors: INGRAM, Lonnie, O. Gainesville, FL 32606 (US) YOMANO, Lorraine, P. Alachua, FL 32615 (US) YORK, Sean, W. Gainesville, FL 32603 (US) (74) Representative: White, Martin Paul et al Fry Heath & Spence,The Old College,53 High Street Horley,Surrey RH6 7BN Horley,Surrey RH6 7BN (GB)