(19)

(11)

EP 0 973 902 A1

(12)

(43) Date of publication: 26.01.2000 Bulletin 2000/04 (21) Application number: 98920832.7 (22) Date of filing: 09.04.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/55, C12N 15/86, C12N 5/10, A61K 48/00, A61K 51/12, A61K 51/04 (86) International application number: PCT/US9807/130 (87) International publication number: WO 9845/443 (15.10.1998 Gazette 1998/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.04.1997 US 835707 (71) Applicant: Human Gene Therapy Research Institute Des Moines, 50309-9976 (US)	(72) Inventors: MANDELL, Robert, B. Des Moines, IA 50309-9976 (US) LINK, Charles, J., Jr. Des Moines, IA 50309-9976 (US) (74) Representative: Thomson, Paul Anthony  Potts, Kerr & Co.,15, Hamilton Square Birkenhead,Merseyside CH41 6BR Birkenhead,Merseyside CH41 6BR (GB)