(19)

(11)

EP 0 973 933 A1

(12)

(43) Date of publication: 26.01.2000 Bulletin 2000/04 (21) Application number: 98908538.6 (22) Date of filing: 13.02.1998

(51) International Patent Classification (IPC)7: C12P 21/04, C12P 21/08, C07K 16/00, C07H 21/04, C12Q 1/70, G01N 33/53, A61K 39/00, A61K 39/21, A61K 39/395 (86) International application number: PCT/US9802/766 (87) International publication number: WO 9836/087 (20.08.1998 Gazette 1998/33)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.02.1997 US 40581 P (71) Applicant: AMERICAN NATIONAL RED CROSS Falls Church, VA 22042 (US)	(72) Inventors: SCOTT, David Bethesda, MD 20817 (US) ZAMBIDIS, Elias,University of Rochester Rochester, NY 14642 (US) (74) Representative: Jones, Elizabeth Louise et al Frank B. Dehn & Co.,179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)