(19)

(11)

EP 0 974 058 A2

(12)

(88) Date of publication A3: 03.12.1998 (43) Date of publication: 26.01.2000 Bulletin 2000/04 (21) Application number: 98915313.5 (22) Date of filing: 07.04.1998

(51) International Patent Classification (IPC)7: G01N 33/68, A61K 48/00, C12N 15/12, C12N 1/21, C12N 5/10, C12Q 1/48, A61K 31/70, C07K 14/47, C12N 15/62, G01N 33/53, C12N 15/11, C12Q 1/68, C07K 19/00, G01N 33/60, A61K 38/17 (86) International application number: PCT/US9806/801 (87) International publication number: WO 9845/712 (15.10.1998 Gazette 1998/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 08.04.1997 US 42728 08.04.1997 US 42754 08.04.1997 US 42825 08.04.1997 US 42727 08.04.1997 US 42726 30.05.1997 US 48184 30.05.1997 US 48068 30.05.1997 US 48070 (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) RUBEN, Steven, M. Olney, MD 20832 (US) YU, Guo-Liang San Mateo, CA 94403 (US) NI, Jian Rockville, MD 20852 (US) FENG, Ping Gaithersburg, MD 20878 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)