(19)

(11)

EP 0 975 628 A1

(12)

(43) Date of publication: 02.02.2000 Bulletin 2000/05 (21) Application number: 98915368.9 (22) Date of filing: 07.04.1998

(51) International Patent Classification (IPC)7: C07D 409/12, A61K 31/535, A61K 31/38 (86) International application number: PCT/US9806/989 (87) International publication number: WO 9845/286 (15.10.1998 Gazette 1998/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 09.04.1997 US 43118 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventor: GLASEBROOK, Andrew, Lawrence Zionsville, IN 46077 (US) (74) Representative: Denholm, Anna Marie et al Eli Lilly and Company Limited,Lilly Research Center,Erl Wood Manor Windlesham,Surrey GU20 6PH Windlesham,Surrey GU20 6PH (GB)