(19)
(11) EP 0 975 750 A2

(12)

(88) Date of publication A3:
05.11.1998

(43) Date of publication:
02.02.2000 Bulletin 2000/05

(21) Application number: 98908570.9

(22) Date of filing: 19.02.1998
(51) International Patent Classification (IPC)7C12N 15/12, C07K 14/47, A61K 31/70, A61K 38/17, C12N 5/10
(86) International application number:
PCT/US9803/041
(87) International publication number:
WO 9837/091 (27.08.1998 Gazette 1998/34)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 20.02.1997 US 38118 P

(71) Applicants:
  • Board of Regents,The University of Texas System
    AustinTexas 78701 (US)
  • BAYLOR COLLEGE OF MEDICINE
    Houston, TX 77030 (US)

(72) Inventors:
  • XU, Hong-Ji
    The Woodlands, TX 77381 (US)
  • HU, Shi-Xue
    The Woodlands, TX 77381 (US)
  • BENEDICT, William, F.
    The Woodlands, TX 77381 (US)
  • ZHOU, Yunli
    Brookline, MA 02146 (US)

(74) Representative: Gowshall, Jonathan Vallance 
FORRESTER & BOEHMERTFranz-Joseph-Strasse 38
80801 München
80801 München (DE)

   


(54) MODIFIED RETINOBLASTOMA TUMOR SUPPRESSOR PROTEINS