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EP 0 975 963 A1

(12)

(43) Date of publication: 02.02.2000 Bulletin 2000/05 (21) Application number: 98910252.0 (22) Date of filing: 09.03.1998

(51) International Patent Classification (IPC)7: G01N 33/48, G01N 33/53, G01N 33/573, A01N 37/18, A61K 38/00, A61K 38/04, C07K 5/00, C07K 7/00, C07K 16/00, C07K 17/00 (86) International application number: PCT/US9804/557 (87) International publication number: WO 9840/738 (17.09.1998 Gazette 1998/37)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 11.03.1997 US 40174 P (71) Applicant: Sloan-Kettering InstituteFor Cancer Research New York,New York 10021 (US)	(72) Inventors: ROTHMAN, James New York, NY 10021 (US) BLOBEL, Carl New York, NY 10021 (US) ROGHANI, Monireh New York, NY 10021 (US) (74) Representative: Schwarz, Albin, Dr. et al PatentanwaltWipplingerstrasse 32/22 1010 Wien 1010 Wien (AT)