(19)

(11)

EP 0 977 585 A1

(12)

(43) Date of publication: 09.02.2000 Bulletin 2000/06 (21) Application number: 98902655.4 (22) Date of filing: 22.01.1998

(51) International Patent Classification (IPC)7: A61K 39/00, C07K 14/705, C07K 16/18 (86) International application number: PCT/US9801/110 (87) International publication number: WO 9832/460 (30.07.1998 Gazette 1998/30)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.01.1997 US 35896 P (71) Applicant: CENTER FOR BLOOD RESEARCH, INC. Boston, MA 02115 (US)	(72) Inventors: WAGNER, Denisa, D. Wellesley, MA 02181 (US) DONG, Zhao, Ming Chestnut Hill, MA 02167 (US) (74) Representative: Ruffles, Graham Keith  MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)