(19)

(11)

EP 0 977 860 A1

(12)

(43) Date of publication: 09.02.2000 Bulletin 2000/06 (21) Application number: 98918666.3 (22) Date of filing: 23.04.1998

(51) International Patent Classification (IPC)7: C12N 15/18, C12N 15/85, C12N 5/10, C07K 14/48, A61K 38/18 (86) International application number: PCT/US9808/242 (87) International publication number: WO 9849/308 (05.11.1998 Gazette 1998/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 25.04.1997 US 845541 29.04.1997 US 841045 (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)	(72) Inventors: PRESTA, Leonard, G. San Francisco, CA 94109 (US) URFER, Roman CH-4056 Basel (CH) WINSLOW, John, W. El Grenada, CA 94018 (US) (74) Representative: Kiddle, Simon John et al Mewburn Ellis,York House,23 Kingsway London WC2B 6HP London WC2B 6HP (GB)