(19)

(11)

EP 0 977 880 A2

(12)

(88) Date of publication A3: 25.03.1999 (43) Date of publication: 09.02.2000 Bulletin 2000/06 (21) Application number: 98922042.1 (22) Date of filing: 21.04.1998

(51) International Patent Classification (IPC)7: C12N 15/85, C12N 9/00, C12N 15/86, C12N 15/11, A61K 31/70, A61K 48/00 (86) International application number: PCT/US9808/003 (87) International publication number: WO 9848/027 (29.10.1998 Gazette 1998/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.04.1997 US 44492 P 09.05.1997 US 46146 P (71) Applicant: UNIVERSITY OF FLORIDA Gainesville, FL 32603 (US)	(72) Inventors: HAUSWIRTH, William, W. Gainesville, FL 32608 (US) FLANNERY, John, G. Berkeley, CA 94720-2020 (US) (74) Representative: Glawe, Delfs, Moll & Partner  PatentanwälteRothenbaumchaussee 58 20148 Hamburg 20148 Hamburg (DE)